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We validate the performance and optimality of our method on both synthetic and real-world data. Additionally, we demonstrate the applicability of the proposed method for two applications refocusing and stylization. Low-intensity ultrasound can stimulate excitable cells in a noninvasive and targeted manner, but which parameters are effective has remained elusive. This question has been difficult to answer because differences in transducers and parametersfrequency in particularlead to profound differences in the stimulated tissue volumes