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lusal support. Dental personnel need to carefully examine dentition conditions to assess the risk of occlusal collapse. Danggui-shaoyao-san (DSS), a representative formula of Traditional Chinese Medicine (TCM) for promoting blood circulation and diuresis (Huo-Xue-Li-Shui) therapy, has been used to clinically nephrotic syndrome (NS) and relieve nephrotic edema. To explore the effects and mechanisms of DSS in improving sodium retention and to identify the bioactive compounds from DSS. DSS prescriptions were disassembled into Yangxue-Huoxu