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Multivariate analysis revealed that age 75 years (odds ratio [OR], 2.1746; P= .0232), respiratory disease comorbidity (OR, 4.3869; P= .0002), cT3-4 (OR, 2.0143; P= .0477), extended surgery duration (OR, 2.3406; P= .0152), and posterior mediastinal reconstruction (OR, 0.1432; P= .0439) were independent risk factors for acute pneumonia. Post-esophagectomy pneumonia in the acute phase was an independent prognostic factor, whereas advanced age, respiratory disease comorbidity, and extended surgery duration were risk factors for acute pn