https://www.selleckchem.com/pr....oducts/super-tdu.htm
64, positive predictive value 0.76, negative predictive value 0.74, and area under the receiver's operating curve (AUC) 0.77, in classifying tumors harboring a BRCA1/2 defect from the rest. These findings indicate that the assessment of CNV and promoter DNA methylation in BRCA1/2 increases the cumulative diagnostic yield by 10%, compared with the 20% yield achieved by sequence variant analysis alone. Genomic DNA methylation data can partially predict BRCAness in ovarian tumors; however, further investigation in expanded BRCA1/2 cohort
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