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Copyright © 2020 Zhang, Zheng, Li, Fu, Li, Su, Zeng, Liu, Wang, Huang, Xu, Ye, Liu and Wang.Common adjustable immunodeficiency (CVID) is one of regular main immunodeficiency (PID) in adulthood and it is described as serious decrease in immunoglobulin serum levels and damaged antibody production in reaction to vaccines and pathogens. Beyond the susceptibility to infections, CVID encompasses a wide spectral range of medical manifestations associated with a complex immune dysregulation which also