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Accordingly, in this review, we have highlighted fluoride-mediated apoptosis via two vital pathways, mitochondrial-mediated and endoplasmic reticulum stress pathways. This review also elaborates on new cellular energetic, apoptotic pathways and therapeutic strategies targeted to treat fluorosis.Purpose The automatic analysis of ultrasound images facilitates the diagnosis of breast cancer effectively and objectively. However, due to the characteristics of ultrasound images, it is still a challenging task to achieve analyzation automatical