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ic manner. Better understanding of the protective duration of prior SARS-CoV-2 infection against reinfection is needed. Primary To assess the durability of immunity to SARS-CoV-2 reinfection among initially unvaccinated individuals with previous SARS-CoV-2 infection. Secondary Evaluate the crude SARS-CoV-2 reinfection rate and associated characteristics. Retrospective observational study of HealthVerity data among 144,678,382 individuals, during the pandemic era through April 2021. Individuals studied had SARS-CoV-2 molecular diagnostic