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Stimulants Are the Most Effective ADHD Medication For Adults Stimulants are among the most commonly prescribed prescription drugs that doctors utilize to treat ADHD in adults. They work by increasing levels of certain chemicals (neurotransmitters) in your brain to improve concentration and decrease impulsivity. Antidepressants such as Strattera (atomoxetine), Wellbutrin/Zyban, and Bupropion (bupropion) are also able to aid in the treatment of ADHD. They boost the levels o