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Histological analyses showed that SVF treatment stimulated the regeneration of the epithelium by promoting numerous enlarged hyperproliferative zones. SVF restored CD24 /lysozyme and Paneth cell populations in the ISC compartment with the presence of Paneth Ki67 cells. SVF has an anti-inflammatory effect by repressing pro-inflammatory cytokines, increasing M2 macrophages in the ileum and anti-inflammatory monocyte subtypes CD11b Ly6c CX3CR1 in the spleen. Through the pleiotropic effects that contribute to limiting radiation-induced lethal