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50, 95% CI1.79-3.51, P less then 0.001) and PFS (HR 1.77, 95% CI1.51-2.01, P less then 0.001). Subgroup analyses were consistent with the pooled results. Similarly, the pooled results for PLR showed that elevated PLR was related to inferior OS (HR 1.93, 95% CI 1.51-2.01, P less then 0.001) and PFS (HR 1.57, 95%CI 1.30-1.90, P less then 0.001). However, the subgroup analysis based on test time indicated that there was no significant correlation between post-treatment PLR and survival outcomes. Conclusion NLR and pre-treatment P