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Finding the Best ADHD Medication For Adults Stimulants, like methylphenidate (Ritalin) or amphetamine (Vyvanse) can be used quickly to increase and stabilize levels of brain chemicals. These drugs can cause a loss of appetite, sleep problems, weight changes and tics in certain people. Atomoxetine, as well as certain antidepressants like bupropion, are all non-stimulants which work slowly to treat ADHD symptoms. They increase a chemical in the brain that is known as norepineph