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This framework may serve as a platform for evaluating the interpretability of any deep network for diagnostic decision-making.Karyopherin subunit alpha 2 (KPNA2) has been reported as an oncogene and is involved in the metabolic reprogramming in cancer. This study aimed to explore the function of KPNA2 in the growth and glycolysis in colon cancer (CC) cells. Differentially expressed genes in multiple CC types were screened in the Oncomine database. KPNA2 was suggested to be highly expressed in CC according to the bioinformatics analyses. High expression of K