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Many medical and genomic prognostic resources have shown quality in pinpointing patients at high belated recurrence threat, but just the BCI prognostic score had been proven to also be predictive of response to extensive endocrine treatment. Nonetheless, all of the evidence readily available on extended hormonal treatment in premenopausal customers had been based on trials in which patients were treated with tamoxifen alone and are also hardly relevant to the current medical scenario. In realit