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pylori-derived OMVs from hosts with different gastric diseases. Western blotting revealed the increased phosphorylation and reduced degradation of inhibitor of NF-κB alpha in cells exposed to OMVs. H. pylori-derived OMVs may aid the development of various gastric diseases by inducing IL-8 production and NF-κB activation. H. pylori-derived OMVs may aid the development of various gastric diseases by inducing IL-8 production and NF-κB activation.We would like to thank Dr Ewington et al. for the commentary on our review about prognostic fac