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Prescription opioid analgesics have contributed to the development of opioid use disorder (OUD) in many individuals. We aimed to characterize non-cancer opioid prescribing for opioid-naive individuals prior to OUD identification. Population-based retrospective cohort study using six linked health administrative databases. British Columbia (BC), Canada. People with OUD between 1January 2001 and 30September 2018 who initiated opioid analgesic therapy for non-cancer pain prior to OUD identification. Dose (morphine milligram equivalent p