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Genetic ablation of MEK2 O-GlcNAcylation at Thr13 abrogated its ability to promote the proliferation and migration of breast cancer cells. Together, our data demonstrate O-GlcNAcylation of MEK2 might be a key regulatory mechanism during tumorigenesis and is a potential therapeutic target for tumor treatment.Children's sleep quality and duration are important to overall development, health, and wellbeing. However, measuring children's sleep is challenging - especially in situations where objective assessment is impractical. This study aim