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Furthermore, this knowledge reveals avenues for attenuating the negative effect of risk-conferring alleles by exposing the epigenome as an exploitable target for therapeutic intervention in OA.Alongside language and bipedal locomotion, tool use is a characterizing activity of human beings. Current theories in the field embrace two contrasting approaches "manipulation-based" theories, which are anchored in the embodied-cognition view, explain tool use as deriving from past sensorimotor experiences, whereas "reasoning-based" theories sugges