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ut coping in order to reduce burdens of chronic pain or fatigue symptoms in certain patients and in actual treatment circumstances. Future studies are needed to continue the development of this fallible theory. Such research will further support decisions about using, designing, allocating, and tailoring serious gaming to optimize important patient health benefits. TRIAL REGISTRATION Netherlands Trial Register NTR6020; https//www.trialregister.nl/trial/5754. ©Miel AP Antonius Petrus Vugts, Aglaia MEE Zedlitz, Margot CW Joosen, Hube