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As there are different kinds of cancerous mesenchymal tumours, biopsy accompanied by immunohistochemistry and electron microscopy however presents a good diagnostic choice and surgical resection is normally the gold standard in these cases. V.OBJECTIVE We provide a set of twins discordant for low-level mosaic trisomy 17 at amniocentesis, so we review the literature of heterokaryotypic monozygotic twins at amniocentesis. PRODUCTS AND METHODS We explain a monozygotic double pregnancy with discordant karyotype