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ADHD OTC Medication The majority of children and adults who use ADHD medications will experience adverse effects. These include heartbeat changes, loss of appetite and upset stomachs. Healthy eating and enough sleep can reduce these side effects. Stimulant drugs boost communication between brain cells, assisting children focus and manage impulses. However, they can also cause tics and increase blood pressure. These are controlled substances that can be crushed or inhaled to create illegal