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Previous study drew different conclusions on significant differences between saline and balanced crystalloid solution infused in critical illness but both showed a statistical difference in the sepsis subgroup. Thus, we will specifically focus on septic patients in this study to compare the effects of saline and balanced solution. We hypothesize that effects of saline onrenal outcomes are related to the underline acute kidney injury (AKI) severity and total volumes of infusion. The investigators designed a pragmatic, multi-center paralle
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