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How Does ADHD Medication Work? The drugs reduce ADHD symptoms by increasing levels Dopamine and Noradrenaline. These are chemicals that transmit messages between brain cells. The most commonly prescribed stimulants are methylphenidate, the atomoxetine and the glycine. Finding the right dosage and medication will require a lot of trial and trial and. Communication with your doctor must be honest and open. Stimulants The stimulant medications prescribed for ADHD increase levels of the