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ADHD Stimulant Medication Around 70% to 70% to with ADHD benefit from stimulants. They ease symptoms by increasing levels of dopamine and norepinephrine. These medications start working in 30 to 45 minutes and last between 3 and 6 hours. These medications are available in chewable or liquid tablet in tablet form. Nonstimulant drugs could be prescribed by your physician to help you take stimulants in conjunction. These include atomoxetine as well as guanfacine.