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Medications and Therapy For ADHD Combining medication and therapy can help to manage ADHD. treats the brain, while therapy helps people cope and learn skills. Stimulants, such as the methylphenidate and lisdexamfetamine, boost levels of two chemicals in the brain that pass messages between cells. This can increase the level of attention, impulse control, and motivation. The stimulants can trigger side effects such as loss of appetite, trouble sleeping, and an increased heart rate and blood pre