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Here, this review article summarizes few of the structural modifications that are performed with PNA, methods used to improve their cellular uptake and shedding light on the applications of PNA in various prospects in biological sciences.Seaweeds are considered a promising functional food and safe for human consumption as they have significant health benefits. Five abundant tropical seaweeds, Caulerpa racemosa var. macrophysa, Caulerpa scalpelliformis, Grateloupia indica, Sargassum linearifolium, and Spatoglossum asperum rich in metabol