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The Na displacement is validated using distortion index parameters from diffraction data and atomic displacement parameters from PDF data. The C2/c supercell is faulted, as evidenced by the increased breadth of the superstructure diffraction peaks. DIFFaX simulations and structural considerations with a two-phase approach were employed to derive a suitable faulting model.Herein, we developed hybrid DNAzyme nanoparticles (NPs) to achieve light-induced carrier-free self-delivery of DNAzymes with sufficient cofactor supply and lysosome esc