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However, smoking significantly increased the failure rate (hazard ratio, 10.7; =0.002). The 5-year CSR of implants placed in regenerated bone using GBR was comparable to that of implants placed in native bone. Smoking significantly increased the risk of implant failure in both groups. The 5-year CSR of implants placed in regenerated bone using GBR was comparable to that of implants placed in native bone. Smoking significantly increased the risk of implant failure in both groups. Vitamin D deficiency may cause bone loss and increased inf