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Aim To investigate associations of psychosocial stressors and resilience factors with DNA methylation age in saliva of Latinx children of immigrants before and after the 2016 presidential election (2015-2018). Materials methods We compared psychosocial exposures with four distinct measures of epigenetic age assessed in saliva of children (6-13 years, n = 71 pre-election; n = 35 post-election). Exploratory genome-wide analyses were also conducted. Results We found distinct associations across epigenetic clocks and time points for example, grea