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3% had normal lung function, COPD, and PRISm, respectively. Patients with PRISm had poorer overall survival than those with COPD or normal lung function in NSCLC and SCLC (Mantel-Cox log-rank test, p 0.05). In the risk-adjusted analysis, overall survival was independently associated with COPD (hazard ratio [HR] 1.209, p=0.027) and PRISm (HR 1.628, p 0.001) in NSCLC, but was only associated with PRISm (HR 1.629, p=0.004) in SCLC. PRISm is a significant pattern of lung function in patients with lung cancer. At the time of lung c