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l status (AOR = 3.610 (95%CI = 1.649-7.901)), opportunistic infection (AOR = 3.122 (95%CI = 1.700-5.733)), and medication adherence (AOR = 0.470 (95%CI = 0.266-0.831)) were significantly associated with depression. Conclusion and Recommendation. From the findings of this study, it is possible to conclude that depression was highly prevalent among people living with HIV/ADS. Sex, marital status, opportunistic infection, and medication adherence were found to be associated with depression and need attention from the health professional wor