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The major gender difference is that the metabolic brain network was delineated into four modules in old female group with the nodes related to sensorimotor function split into two modules. Discussion Those findings suggest aging is associated with reorganized brain modular architecture. Clinical Trial Registration number ChiCTR2000036842. With recent technological advancement, new and improved endoscopic instruments and laser devices have catapulted flexible ureteroscopy (fURS) to the forefront, hence making retrograde intrarenal surger