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ded with respect to its specific mechanisms of action, its efficacy in reinforcing health-promoting modes of be - havior, differential indications for different patient groups, and the cost-efficiency of the technique across the spectrum of disorders in which it is used. The purpose of neonatal screening is the early detection of congenital metabolic and endocrine disorders that, if untreated, could lead to fatal crises or other long-term adverse sequelae. In Germany, neonatal screening is legally regulated. Quality-assurance reports ("DG