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As endothelial cells (ECs) and vascular smooth muscle tissue cells (VSMCs) are necessary parts within the internal and medial levels of vessel wall, correspondingly, the architectural and practical modifications of ECs and VSMCs would be the significant reasons of vascular ageing. Milk fat globule-epidermal growth element 8 (MFG-E8) is a multifunctional glycoprotein which exerts a regulatory role in the intercellular communications involved in a variety of b