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9 nm and 110.6 nm for Cur NP+VC and CCNP+VC respectively. The curcumin encapsulated in the Cur NP+VC and CC+VC nano-scaffolds showed a release profile of 60% and an improved antioxidant activity of greater than 80%. The nano-scaffolds were antagonistic against Escherichia coli and Staphylococcus aureus, and likewise enhanced wound healing capacity of 85.62 % and 77.05% was observed in murine cell line. The curcumin nano-scaffold is a biodegradable and effective drug delivery system for topical use that can act as an antioxidant, fa