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Background The ubiquitin-proteasome pathway is crucial for all cellular processes and is therefore a critical target for the investigation and development of novel strategies for cancer treatment. In addition, approximately 30% of newly synthesized proteins never attain their final conformations due to translational errors or defects in posttranslational modifications; therefore, they are also rapidly eliminated by the ubiquitin-proteasome pathway. Objective Here, we have tried to outline the recent findings deciphering the new molecular