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Fluid commonly flows in response to an external pressure gradient. However, when a tunnel-containing hydrogel is immersed in water, spontaneous flow occurs through the tunnel without any pressure gradient. We confirmed this flow in a wide range of plant- and animal-derived hydrogels. The flow appears to be driven by axial concentration gradients originating from surface activities of the tunnel wall. Those activities include (i) hydrogel-water interaction and (ii) material exchange across the tunnel boundary. Unlike pressure-driven flow,