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[Value of Blended Diagnosis involving Cytokines and also Tumor Indicators from the In contrast, a JNK activator, anisomycin, partially abolished the effects of SP600125 on Prss14/epithin shedding. Moreover, results from loss-of-function experiments with specific inhibitors, short hairpin RNA-mediated knockdown, and overexpression of dominant-negative PKCβII variants indicated that PKCβII is a major player in both JNK inhibition- and PMA-mediated Prss14/epithin shedding. SP600125 increa