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Versatile lipid membrane-inserting nanopores were made by functionalizing DNA nanostructures with hydrophobic tags. Here, we lay out design and considerations to get DNA nanopores aided by the desired proportions and conductance properties. We further provide assistance with their reconstitution into lipid membranes.Membrane protein pores have actually demonstrated applications in nanopore technology. Earlier research reports have mainly centered on β-barrel protein pores, whereas α-helix-base