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GDF-8 has a regulatory role and potential importance in ovarian reproductive activity and may be involved in folliculogenesis, ovulation, and early embryo implantation. This study aimed to assess the impact of different antidiabetic agents on individuals with diabetes and COVID-19. We searched PubMed, Web of Science, Embase, and Cochrane Library databases from inception to October 31, 2021 and included seven antidiabetic agents. The data were pooled traditional pairwise meta-analysis and Bayesian network meta-analysis. The pairwise meta-an