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ADHD Medications - Stimulant Or Non Stimulant? For many people stimulant medication is the first choice to treat ADHD. Certain people experience side effects or they don't work. Doctors may prescribe non-stimulant ADHD medication instead, or in conjunction with stimulants. These medications include those that treat high blood pressure, for instance Clonidine and Guanfacine hcl (Tenex). These are in addition to other medicines that help to increase wakefulness. Benefit