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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medications are the first-choice treatment for ADHD and for many people, they are effective. Some suffer from side effects or they don't perform as well. Doctors sometimes prescribe non-stimulant ADHD medications instead, or in combination with stimulants. These include medicines that treat high blood pressure, such as clonidine or guanfacine (Tenex). These are am