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Among UK individuals, antibody-dependent NK cell IFN-γ responses to iRBC were influenced by IL-18 whereas among Gambians, the prevalent adaptive FcεR1γ- NK cell response ended up being IL-18 (and accessory cell) independent (although the low frequency reaction of canonical FcεR1γ NK cells did rely on this cytokine). Copyright © 2020 Sherratt, Patel, Baker, Riley and Goodier.Chimeric antigen receptor (CAR) T cellular effectiveness against solid tumors is limited by several immune escape s