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(2) techniques We completed a systematic literary works search on CNO with mandibular involvement, based on the "Preferred Reporting Items for Systematic Reviews and Meta-Analyses" (PRISMA) directions, considering the different synonyms for CNO, with an unique target therapy. (3) outcomes Finally, only four researches might be included. A complete of 36 clients had been addressed in these studies-therefore, for the most part, only tendencies might be identified. The therapy when you look