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So the authors designed this meta-analysis to more precisely estimate relationship between TNF-α polymorphisms and periodontitis by pooling the outcomes of already published relevant researches. METHODS The authors searched Pubmed, Embase, Web of Science and CNKI for currently posted researches. Forty-five already published researches were pooled analyzed in this meta-analysis. RESULTS The crude pooled meta-analyses outcomes showed that distributions of TNF-α rs361525, r