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citrifolia for the first time. All isolated compounds were evaluated for their anti-rheumatoid arthritis activities via examining their inhibitory activities on the proliferation of synoviocytes in vitro using MTS met-hod. Compounds 1-11 showed significant anti-rheumatoid arthritis activities, displaying the inhibitory effects on the proliferation of MH7 A synovial fibroblast cell with the IC_(5 values ranging from(38.69±0.86) t203.45±1.03) μmol·L~(-1).This paper aims to investigate the chemical constituents of the seeds of Herpet