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The magnitude of association between statin use and post-stroke seizures (PSS) risk remains unclear. Therefore, the aim of this meta-analysis was to evaluate this issue. We systematically searched electronic libraries, including Medline, Embase, and Cochrane databases, for relevant clinical studies. The main outcome was the risk of early PSS and the risk of post-stroke epilepsy (PSE). The pooled relative risks (RRs) and the corresponding 95% confidence intervals (CIs) were used to calculate the association between statin treatment and r