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6%) during a 5year follow-up. A quarter of patients with hypertensive LV hypertrophy and HFpEF progresses to systolic dysfunction during a 5year follow-up, which was accompanied by poor clinical outcomes. And beta-blocker therapy might play a protective role for preserved LVEF in this population. A quarter of patients with hypertensive LV hypertrophy and HFpEF progresses to systolic dysfunction during a 5 year follow-up, which was accompanied by poor clinical outcomes. And beta-blocker therapy might play a protective role for preserved