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Multimodal neuroimaging provides a rich source of data for identifying brain regions associated with disease progression and aging. However, present studies still typically analyze modalities separately or aggregate voxel-wise measurements and analyses to the structural level, thus reducing statistical power. As a central example, previous works have used two quantitative MRI parameters-R2* and quantitative susceptibility (QS)-to study changes in iron associated with aging in healthy and multiple sclerosis subjects, but failed to simult