https://azd1390inhibitor.com/m....id-term-outcomes-soo
We show that TGF-β causes a deeper senescent condition under hypoxia than under normoxia; deep senescence correlates aided by the level of E2F suppression and it is marked by multinucleation, paid off reentry into proliferation, and a distinct 14-gene SASP. Controlling TGF-β signaling in tumors in an immunocompetent mouse lung cancer model abrogates endogenous senescent cells and suppresses the 14-gene SASP and immune infiltration. Untreated man lung types of canc
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