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Conduct the distinctions of entire genome sequence and some viral proteins to look for the gap as well as the change alternation of nucleotides and amino acids sequences. We evaluate 11 complete genome series of different coronavirus using BAST and MAFFT pc software. We additionally picked 7 forms of architectural proteins. We were conclude that COVID-19 may be created brand-new mutations especially in glycoproteins therefore calls for care and full preparation by wellness authoriti